How can be managed unique products?

I see that erpnext allows to create a serial number for the variant, in our case they are unique products (second hand), then this feature is perfect. But there are any way to find products in sales / pos by serial number and if this product is sold off that variant forever (are they unique products that can not be sold more than once)?

If not, with your experience would it be very complex to adapt the system to this functionality?

Yes, serial nos are unique in erpnext and I think you can search the items with serial no in sales/pos. One serial can not be sold twice, that valuation is there.

Perfect, could be very difficult make that when a product variant with serial number is selled mark it as disabled? That variant never will be restocked, it is a unique product.