I changed in desk.min.js file. Increased file size because i can’t upload profile picture and others file. Changed work if i use “sudo supervisorctl reload” command but problem is then if i use “bench start” it stopped showing log in terminal. So if i want to see log in terminal then i need to use " sudo supervisorctl stop all " and start the bench. If i use “sudo supervisorctl stop all” command then my changed in desk.min.js file disappeared. I use “bench build” also it also disappeared my changes.
I think you must purge \ clear REDIS cache… But I don’t know how to do 
@jewel if you already found any solution to solve this problem please share me asap.
Dear @jewel
Finally, I found a solution after 3 months from I met this problem.
You need just to run bench build command to rebuild all items.
P.S. You must run this command on frappe-bench directory to access bench.